In this talk, we will present the applications of inverse scattering principles with digital holography [1-5]. First, I will present the holotomography – a 3D quantitative phase imagign techniques for label-free imaging of cells and tissues [2]. As an optical analogous to X-ray computed tomography, holotomography reconstructs 3D refractive index tomography of unlabelled cells, from multiple 2D holographic images obtained with various illumination angles. The obtained 3D refractive index tomograms are then analyzed using deep-learning for various applications, including cell biology and infectious diseases [3]. Second, we also discuss the applications of inverse scattering principle for highly scattering layers. By wavefront of light impinging onto a highly scattering sample, we demonstrate the control and measurement of evanescence near fields, the demonstration of high-definition 3D holographic display, and the optical phase conjugation only using simple linear optics [4-5].

[1] Park JC et al., Nature Communications 10 :1304 (2019)

[2] Park YK et al., Nature Photonics 12 :578 (2018)

[3] Jo Y et al., Science Advances, 3 (2017)

[4] Yu H et al., Nature Photonics, 11 :186 (2017)

[5] Kim K and Park YK, Nature Communications, 8:15340 (2017)